HTML Grid Layout Panel - should this control be used?

I am fairly new to ASP.NET. All the ASP.NET books I'm reading specify that web forms should be designed in Flow Layout mode rather than Grid Layout mode. I'm doing this with all my pages and for the most part everything is working fine.

There are some areas on my web pages, however, where I would like to have a little more control on control placement (rather than using a whole lot of tables to control positioning). The HTML Grid Layout Panel control seems well suited for this. My question is, are there any reasons why this control should be avoided (e.g. is it similar to using the Grid Layout mode for web pages which, apparently, should be avoided)? I don't want to run into a situation where I do a lot of work with HTML Grid Layout Panels, only to discover there are issues or browser compatibility problems.

Thanks!